Angiotensin-converting enzyme gene polymorphism, carotid intima-media thickness, and left ventricular mass index in adolescent hypertension J Clin Ultrasound.
DOI: Methods: We studied hypertensive and 58 normotensive control adolescents.
ACE gene polymorphism was determined by a standardized method. The severity of hypertension was graded according to the results of ambulatory blood pressure monitoring as white coat, borderline, or proven hypertension.
The association between ACE gene polymorphism and the obtained parameters was analyzed using analysis of variance and chi-square testing. The severity of hypertension as assessed by ambulatory blood pressure monitoring was independent of the ACE genotype.
Conclusions: Target-organ damage left ventricular hypertrophy and carotid atherosclerosis is detectable in adolescents with hypertension and, in those subjects, ACE genotype polymorphism is not correlated with the severity of target-organ damage as measured by IMT and LVMI.
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